The brain-gut connection is a major aspect of SIBO that is often not fully addressed. SIBO can lead to the manifestation or exasperation of depression, anxiety, insomnia and/or OCD. SIBO affects the nervous system with the gut and throughout the body. SIBO activity can result in neuropathies and cognitive changes often blamed on other chronic infections, autoimmune disorders or the aging process. SIBO often results in chronic immune activity resulting in neurotransmitter imbalances, favoring patterns associated with mood disorders and fatigue.
SIBO symptoms are often mistaken for Lyme disease and SIBO is commonly a problem found in persistent Lyme disease. When co-existing with Lyme disease, SIBO symptoms often mimic past Lyme symptoms and can result in over-treating. Additionally, effectiveness of infectious disease treatments are difficult to accurately monitor if SIBO is part of the picture.
SIBO metabolic waste products challenges the liver detox functions and can lead to sex hormone imbalances, excessive harmful estrogen metabolites, fatty liver and higher levels of ammonia. Most suffers of acne, PCOS and fatty liver suffer from SIBO.
In order to fully recover from SIBO, it is sometimes necessary to "reboot" a number of systems and organs to improve symptoms and reduce reinfection rates. Diagnosis of SIBO is the first step, but a number of other holistic approaches are commonly needed to return to a state of optimal homeostasis.