Struggling with intense mood swings, stress, or PMS symptoms? It might not be “just in your head.” A common gene variant called COMT affects how your body clears stress hormones and estrogen by-products. When COMT is slow, brain chemicals like dopamine and adrenaline linger longer—amplifying anxiety, irritability, and hormone-related symptoms like those seen in PCOS or PMDD. Learn how to support COMT naturally with food, lifestyle, and targeted nutrients.

PCOS is more than a hormone issue—it involves the liver, gut, and metabolism. This blog explores three powerful supplements that support estrogen balance, mood, digestion, and detox: SAMe (for methylation and liver support), calcium D-glucarate (to reduce estrogen recirculation), and digestive enzymes with ox bile and HCl (to improve bile flow and nutrient absorption). Together, they target root causes to support clearer skin, better cycles, and more stable energy.

PCOS isn’t just about high androgens or irregular cycles—it’s a complex condition involving metabolism, inflammation, gut health, and liver function. Estrogen “excess” often stems from poor detoxification, not just overproduction. Supporting liver pathways, improving bile flow, and addressing gut imbalances like SIBO can make a big difference. A holistic approach targets the why behind hormone imbalance—helping restore cycles, mood, skin, and energy.

Many people don’t realize the gallbladder plays a key role in hormone balance and gut health. Bile, produced by the liver and stored in the gallbladder, helps detoxify estrogen and keeps bacteria in check in the small intestine. When bile flow is sluggish, it can lead to bloating, estrogen dominance, and conditions like SIBO. Supporting bile production with herbs, supplements, and liver-friendly foods is essential for relieving digestive issues and restoring hormonal balance.

Estrogen metabolism plays a critical role in hormonal balance and overall health. When this finely tuned process falters, it can lead to estrogen dominance—contributing to symptoms like weight gain, mood swings, and reproductive issues. This article explores how the liver, gut, genetics, and lifestyle factors affect estrogen detoxification and offers natural strategies to support optimal hormone health.

SIBO doesn’t just cause digestive issues—it can also disrupt hormone balance by interfering with estrogen metabolism. It impacts the estrobolome, increases estrogen recirculation, impairs liver detox, and raises inflammatory metabolites. SIBO-related inflammation also raises cortisol, which suppresses sex hormones. Addressing SIBO can support hormone health, restore balance, and relieve symptoms like PMS, low libido, and irregular cycles.